Rios group
We focus on investigating the cellular dynamics governing pediatric cancer progression and treatment response by implementing innovative imaging strategies, using confocal, multiphoton and lightsheet microscopy technologies. By running The Princess Máxima Imaging Center, we ensure that the imaging expertise gained will be applied for studying all subtypes of childhood cancers.
Contact
Anne Rios
Prof. Anne Rios developed a unique imaging technique to visualize intact organ/tumor in 3D, encompassing the entire tissue, down to a sub-cellular resolution within a single biological sample. Her group is now implementing this 3D methodology and other advanced imaging techniques (e.g. intravital, live cell and multiplex imaging) to decipher the cellular and molecular mechanisms governing pediatric cancer progression and treatment response.
“Visualize cancer immunotherapy innovation!”
Prof. dr. Anne Rios
Research group leader
Several research lines have been set up for different (pediatric) cancers, including Diffuse Midline Glioma (DMG). We focus on the interaction of the tumor with its micro-environment and leads that this could provide for cancer targeting. We develop new organoid-based models with increased cellular complexity to study such interactions. In addition, we combine imaging and computational strategies to dissect the mode-of-action of cellular immunotherapies that are now increasingly applied to treat cancer. We hope that this can lead to the identification of therapeutic targets to further enhace their efficacy.
An innovation in our research line is the development of a 3D-stereo-display that uses 3D-glasses to immerse the public inside our imaging data. We believe that this inventive visualisation and our Art&Science initiatives are a strong asset to engage the community into the fight against cancer and create a new trend in communicating science to the scientific community and the public.
Grants and awards
Key publications
- Key publications
Dekkers JF*, Alieva M*, ..., Rios AC. Uncovering the mode of action of engineered T cells in patient cancer organoids (2023). Nature Biotechnology 41: 60-69. *Joint first authors PubMed PMID: 35879361
Van Ineveld RL*, Kleinnijenhuis M*, ..., Rios AC. Revealing the spatio-phenotypic patterning of cells in healthy and tumor tissues with mLSR-3D and STAPL-3D (2021). Nature Biotechnology 10: 1239-1245. *Joint first authors PubMed PMID: 34083793
Dawson CA, ..., Rios AC and Visvader JE. Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling (2020). Nature Cell Biology 22:546-558. PubMed PMID: 32341550
Rios AC, Clevers H. Imaging organoids: a bright future ahead (2018). Nature Methods 1:24-26. PubMed PMID: 29298292
Fu NY*, Rios AC*, ..., Visvader JE. Identification of quiescent and spatially-restricted stem cells in the adult mammary gland (2017). Nature Cell Biology 3:164-176. *Joint first authors PubMed PMID: 28192422
Rios AC*, Fu NY*, ..., Lindeman GJ and Visvader JE. Essential role for a novel population of binucleated mammary epithelial cells in lactation (2016). Nature Comm 7:11400. *Joint first authors PubMed PMID: 27102712
Rios AC*, Fu NY , Lindeman GJ and Visvader JE. In situ identification of bipotent stem cells in the mammary gland (2014). Nature, 506: 322-327. (Article). Joint first authors PubMed PMID: 24463516
Rios AC, Serralbo, O., Salgado, D., Marcelle, C. Neural crest regulates myogenesis through the transient activation of NOTCH (2011). Nature 473: 532-5 (Letter) PubMed PMID: 21572437
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